Menstrual cycle, sex hormones receptors, and the skin
Autoimmune progesterone dermatitis (APD) occurs during the luteal phase of a woman's menstrual cycle and is an uncommon cyclic premenstrual reaction to progesterone
Skin lesions appear during the second half of the menstrual cycle and resolve during the menstrual period; Urticaria, urticaria-like weals, eczema-like lesions, blisters and target lesions Autoimmune hives, or chronic autoimmune urticaria, is a condition that involves red, itchy bumps or welts on the skin, lasts six weeks or longer, and is related to a response from your immune system
Skin lesions occur periodically during the luteal phase of the menstrual cycle due to increases in progesterone
In refractory chronic urticaria, patients can be referred to subspecialists for additional Premenstrual flare-up Autoimmune progesterone dermatitis Smaller wheals Autoimmune progesterone dermatitis: treatment with oophorectomy
J Allergy Clin Immunol
Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity disorder characterized by recurring dermatologic manifestations during the luteal phase of the menstrual cycle in women
Urticaria is a common clinical disorder, pathophysiology based on mediators release from mast cells, predominantly histamine and subsequently an inflammatory response [1]
A typical urticarial lesion is an intensely pruritic, erythematous plaque ( picture 1 )
The low
Furthermore, it does not encompass non-dermatologic manifestations of the disease, such as bronchospasm and anaphylaxis
2 The prevalence of APD is unclear, but ∼ 90 cases have been reported in the English literature